Sintesis Khalkon dan Uji Aktivitas Tabir Surya Secara In Vitro

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis performed by using KOH 40% under stirring at room temperature for 48 h. compounds characterized FTIR, GC-MS 1H NMR spectrometers. Further, the chalcone were screened UV-Vis spectrophotometer. result showed that has succesfully 36.94% Yield. invitro SPF values with maximal protection category consentration 15 µ/mL produce 9.749